在冷试管婴儿/ICSI周期中对质支持协议的比较:一个网络元分析
Neerujah Balachandren1, Meenakshi Veeramani2, Sureka Suriyakumar1
1University College London, UCL EGA Institute for Women's Health, London, UK.
概括
将GnRH激动剂添加到阴道孕激素可以显著提高冷胚胎移植 (FET) 中的临床怀孕率. 这种优化质支持策略 (LPS) 改善了接受FET周期的女性的结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
- 临床试验分析
背景情况:
- 在成功的冷胚胎移植 (FET) 中,体支持至关重要.
- 目前的质支持方案显示出显著的变异性,导致不一致的生殖结果.
研究的目的:
- 确定冷胚胎移植 (FET) 周期中最有效的质支持策略 (LPS).
- 评估影响质支持在FET中的有效性的关键因素.
主要方法:
- 对12个数据库和2个注册表进行了全面的文献搜索.
- 贝叶斯网络对随机对照试验 (RCT) 和涉及4688名参与者的观察性研究进行元分析 (NMA).
- 主要结局包括临床怀孕,活产和流产率.
主要成果:
- 包括14项比较12项干预措施的研究.
- 阴道孕激素与皮下GnRH激动剂单剂或双剂相结合,显著改善了临床怀孕率 (RR 1.86 [95% CrI 1.18,2.93]).
- 偏差风险中等,结果之间网络不一致性较低.
结论:
- 将0.1毫克的皮下GnRH激动剂 (单剂或双剂) 添加到阴道孕激素治疗方案中,长达12周,可以改善FET周期中的临床怀孕.
- 这种增强的质支持策略为优化FET成功率提供了一个有希望的方法.
关键词:
临床怀孕 临床怀孕生育能力 生育能力 生育能力 生育能力冷胚胎转移是如何进行的活生生的出生是活生生的出生.体支 体支是一种支持.流产 流产 流产 流产多重怀孕多重怀孕的情况网络元分析 网络元分析更多相关视频
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