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一个基于的益生菌补充剂试点研究在克罗恩病患者中进行

Haim Leibovitzh^1,2, Naomi Fliss Isakov^1,3, Lael Werner^1,2

¹Department of Gastroenterology and Liver Diseases, IBD Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Journal of dietary supplements

|May 2, 2025

概括

基于的益生菌补充剂在克罗恩病 (CD) 患者中显示出临床改善. 这种干预改变了肠道微生物群,增加了有益的短链脂肪酸产生细菌,并影响了微生物通路.

科学领域:

胃肠病学和肝病学
微生物学微生物学
营养科学营养科学

背景情况:

关于在西方人群中治疗克罗恩病 (CD) 的基于的益生菌补充剂的数据有限.
了解益生菌对CD肠道微生物群的影响对于开发新型治疗策略至关重要.

研究的目的:

评估一种基于的益生菌 ("Mycodigest") 在患有轻度至中度CD的患者的临床疗效.
评估"Mycodigest"对便微生物组成和功能的影响.

主要方法:

进行了一项随机,双盲,安慰剂控制的试点试验.
使用哈维-布拉德肖指数,C反应蛋白和便calprotectin评估了临床疗效.
用DNA枪甲基因组测序分析便样本,以评估微生物组的变化.

主要成果:

与安慰剂 (16.7%,p=0.035) 相比,在"Mycodigest"组 (80%) 观察到显著更高的临床响应率.
干预后,25种细菌物种的丰富差异,包括短链脂肪酸生产者的增加,如Parabacteroides distasonis和Faecalimonas umbilicata.
在服用"Mycodigest"补充剂后,参与异oprenoid代谢的两个微生物途径得到了上调.

结论:

基于的益生菌补充剂在CD患者中显示出临床改善.
这些临床益处可能与便微生物组合和功能的有利变化有关,包括增加的SCFA产生细菌.

关键词:

在C-反应性蛋白质中.克罗恩氏病是什么克罗恩氏病是什么便中的calprotectin是一种便的calprotectin.胃肠道的微生物群是一种真菌.益生菌益生菌前生物

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