gSOS多基因评分与儿童时期的骨密度和骨折风险有关
Jonathan A Mitchell1,2, Jonathan Bradfield3,4,5, Shana E McCormack2,6
1Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia.
概括
骨健康的遗传风险评分 (gSOS) 与儿童更好的骨密度和更少的骨折有关. 这种遗传工具可能有助于改善儿童的骨健康,并防止一生中发生骨折.
科学领域:
- 儿童骨健康研究
- 遗传学和个性化医学
- 定量超声波和骨密度计的使用.
背景情况:
- 基因定量超声速 (gSOS) 的多基因风险评分是在成年人身上开发的,与骨折风险有关.
- 了解gSOS与儿科人口骨健康的关联对于早期干预至关重要.
研究的目的:
- 调查gSOS与儿童骨健康指标之间的关联.
- 评估gSOS作为儿童队列中骨折风险的潜在预测因素.
主要方法:
- 利用来自两个独立的儿科队列的遗传数据:儿童骨密度研究 (BMDCS) 和费城儿童医院 (CHOP).
- 使用遗传变异计算gSOS并通过DXA扫描和电子健康记录的骨折数据评估面积骨矿物质密度 (aBMD).
- 分析了gSOS,aBMDZ分数和骨折概率之间的关联,并对相关共变量进行了调整.
主要成果:
- 在儿童中,较高的gSOS分数与多个骨部位的aBMD Z-score增加显著相关.
- 在gSOS的1 SD增加与12-16%的骨折可能性降低相关. 在两个儿科队列中.
- 这些关联在不同性别,年龄,青春期阶段和生活方式因素中保持一致,特别是在欧洲祖先中.
结论:
- 在儿童中,gSOS与改善骨矿物质密度和减少骨折风险有关.
- 这种遗传风险评分表明,它对改善早期骨健康和减轻整个生命周期的骨折风险具有潜在的临床效用.
- 在儿童群体中,gSOS可以作为个性化骨健康管理的宝贵遗传工具.
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