与急性COVID-19相关的COVID-19疫苗接种时间,以及长期COVID的后续风险
Zachary Butzin-Dozier1, Yunwen Ji1, Lin-Chiun Wang1
1School of Public Health, University of California, Berkeley, Berkeley, CA USA.
概括
在感染之前接种COVID-19疫苗可以降低长期COVID的风险. 在接种疫苗后的7个月内观察到对长期COVID的保护,这表明接种疫苗是关键的预防策略.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 长期COVID是一个严重的健康问题,影响着数以百万计的人,对预防策略的理解有限.
- 接种COVID-19疫苗对于预防急性疾病至关重要,并可能提供对长期COVID的保护.
- 为了最大限度地降低长期COVID风险,最佳的疫苗接种时间需要进一步调查.
研究的目的:
- 评估COVID-19疫苗接种情况与患长期COVID的风险之间的关联.
- 为了确定COVID-19疫苗接种时间是否与急性感染相对影响长期COVID风险.
主要方法:
- 从2021年12月到2022年9月,使用电子健康记录 (EHR) 的回顾性队列研究.
- 长度定向最大概率估计用于分析超过150万患者的数据.
- 长期COVID风险的比较 (ICD-10代码U09.9) 基于疫苗接种状态和与急性COVID-19诊断相对的时间.
主要成果:
- 与未接种疫苗的人相比,接种疫苗的患者患长期COVID的风险较低 (调整后边际风险比率为0.84).
- 在接种疫苗后1至3个月和接种疫苗后3至5个月或5至7个月的急性COVID-19诊断相比,没有发现长期COVID风险的显著差异.
结论:
- 在SARS-CoV-2感染之前的COVID-19疫苗接种表明对长期COVID有保护作用.
- 这种针对长期COVID疫苗接种的保护性益处似乎持续至少七个月.
- 这些发现支持COVID-19疫苗接种作为预防长期COVID的有效措施.
相关概念视频
Vaccinations
43.0K
Overview
43.0K
Immunological Memory
423
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
423
Mechanisms of Retrovirus-induced Cancers
4.9K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
4.9K
Causality in Epidemiology
167
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
167
Factors Affecting the Risk of Infection
10.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
10.6K
Acute Pharyngitis
261
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
261


