植物化学辅助合成,优化和银纳米颗粒对抗微生物活性的表征
Cynthia A Gwada1,2, Prince S Ndivhuwo3,4, Kabo Matshetshe4
1School of Physical and Biological Sciences, Maseno University Private Bag, Maseno Kenya mildredairo@gmail.com +25 4714979279 +27 73 761 0875.
RSC advances
|May 2, 2025
概括
来自植物提取物的绿色合成的银纳米粒子 (AgNPs) 显示出强大的抗菌活性对抗耐药细菌. 这些生物相容的AgNP为打击抗菌素耐药性 (AMR) 提供了一个有希望的替代策略.
科学领域:
- 纳米技术 纳米技术
- 绿色合成是一种绿色合成.
- 抗菌剂 抗菌剂 抗菌剂
背景情况:
- 抗菌素耐药性 (AMR) 的上升构成了全球健康的重大威胁.
- 新型抗生素的有限开发需要替代治疗策略.
- 基于纳米粒子的疗法,特别是银纳米粒子 (AgNPs),正在成为潜在的解决方案.
研究的目的:
- 为了研究绿色合成的银纳米粒子 (AgNPs) 的抗菌性质.
- 使用Ocimum gratissimum (OG),Apium graveolens (AG) 和树 (AA) 的叶片提取物进行AgNP合成.
- 为了评估这些AgNP对格拉姆阴性和格拉姆阳性细菌的疗效.
主要方法:
- 使用植物提取物作为减少,封闭和稳定剂的AgNPs的绿色合成.
- 使用表面等离子共振 (SPR),X射线衍射 (XRD),里埃转换红外光谱 (FTIR) 和能量分散光谱 (EDS) 进行AgNP的表征.
- 对大肠杆菌和黄金杆菌进行抗菌活性测试,确定最小抑制度 (MIC) 和最小杀菌度 (MBC).
主要成果:
- 成功合成了晶体,面中心立方体 (FCC) 金属银纳米颗粒,尺寸在15-28纳米之间.
- AgNPs表现出显著的抗微生物活性,较小的球形颗粒显示出更高的疗效.
- 低至1.016μg mL-1的MIC值,表明强大的抗菌潜力,特别是在对抗像大肠杆菌这样的阴性细菌.
结论:
- 绿色合成的AgNP具有强大的抗菌特性,为传统抗生素提供了可行的替代品.
- 增强的抗微生物有效性归因于与植物化合物的生物相容性和协同效应.
- AgNPs的机制涉及银离子释放和反应性氧物种生成,突出了它们对抗AMR的潜力.
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