在沙特阿拉伯看似健康的个体中血液学参数的参考间隔:系统性审查和元分析
Naila Shaheen1,2,3,4, Seena Thomas1,2,3, Areej Almoghairi2,5,6
1Division of Biostatistics, Department of Population Health, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Frontiers in medicine
|May 2, 2025
概括
这项研究审查了沙特阿拉伯的血液学参考间隔 (RIs),发现了不同地区的差异. 为准确的患者诊断和管理,建议建立特定人群的RI.
科学领域:
- 临床生物化学 临床生物化学
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 血液学参数的参考间隔 (RIs) 对于临床诊断至关重要.
- 沙特阿拉伯现有的RI缺乏标准化,需要对观察性研究进行审查.
研究的目的:
- 系统地审查和对沙特阿拉伯的血液学参数RI进行观测研究进行元分析.
- 为了确定该国不同地区报告的RI的模式和变化.
主要方法:
- 在PubMed和Google Scholar上进行了全面的文献搜索.
- 纳入标准集中在看似健康的个体的观察性研究上,不包括特定的人群和疾病.
- 使用Joanna Briggs Institute (JBI) 检查清单评估方法质量,并使用R.软件进行元分析.
主要成果:
- 包括来自不同沙特地区的12项研究,其中大多数专注于成年人.
- 在所有分析的血液学参数 (例如,红血细胞,Hb,WBC,PLT) 中观察到高异质性.
- 在男性和女性之间观察到红细胞 (RBC) 和血红蛋白 (Hb) 水平的统计学上显著差异,男性的水平更高. 血小板 (PLT) 计数在女性中较高.
结论:
- 在整个沙特阿拉伯,血液学参数的RI存在显著差异.
- 需要为沙特阿拉伯个人建立标准化,特定于人口的RI.
- 标准化的RI将有助于准确的患者转诊和诊断工作,以检查异常血细胞计数.
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