缺血性中风后肠道损伤和肠道微生物群的变化
Yang Shen1,2, Jin Wang1,2, Yina Li3
1Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Frontiers in cellular neuroscience
|May 2, 2025
概括
缺血性中风 (IS) 损害了肠道,改变了肠道细菌,增加了疾病的严重程度. 保护肠道屏障和调节肠道微生物群可以改善IS患者的治疗结果.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 缺血性中风 (IS) 是全球死亡和残疾的主要原因.
- IS显著影响肠道,损害肠道屏障的完整性,改变肠道微生物群的组成.
研究的目的:
- 审查当前关于肠道损伤,肠道微生物群变化和IS后的治疗策略的研究.
- 突出肠道在IS病原和恢复中的作用.
主要方法:
- 关于IS及其对胃肠道系统的影响最近研究的文献综述.
- 对肠道微生物群变化的研究分析,包括细菌组成和代谢物产生.
主要成果:
- IS增加了肠道透性,并允许肠道细菌转移,引发全身炎症.
- 肠道微生物群转向有害细菌,减少像短链脂肪酸 (SCFA) 这样的有益代谢物,增加像三甲基胺N氧化物 (TMAO) 这样的有害代谢物.
- 抗生素和营养支持等疗法可以积极影响肠道微生物群和神经恢复,而反损伤可能会损害肠道.
结论:
- 肠道损伤和肠道失调是IS发展和预后的关键因素.
- 针对肠道粘膜和微生物群提供了有前途的治疗策略,以改善IS患者的治疗结果.
- 个性化治疗方法对于有效管理IS患者至关重要.
相关概念视频
Anatomy of the Intestines
70.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
70.4K
What is Monogastric Digestion?
69.6K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
69.6K
Irritable Bowel Syndrome I: Introduction
201
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
201


