一个四重的病原体参考本体学套件
John Beverley1,2, Shane Babcock1,3, Carter Benson2,4
1National Center for Ontological Research, United States.
ArXiv
|May 2, 2025
概括
像传染病本体学 (IDO) 这样的标准化本体学对于管理传染病数据至关重要. 新的病原体特定扩展 (VIDO,BIDO,MIDO,PIDO) 增强了数据模块化和可重复使用性.
科学领域:
- 生物医学信息学 生物医学信息学
- 传染病研究 传染病研究
- 本体学 工程学 工程学
背景情况:
- 传染病对全球健康构成重大挑战,需要强有力的数据管理策略.
- 标准化本体学,如传染病本体学 (IDO),对于组织和共享传染病信息至关重要.
- 由于COVID-19大流行,需要更新IDO及其特定病毒的扩展,以及细菌,真菌和寄生虫疾病的扩展.
研究的目的:
- 引入传染病本体学 (IDO) 及其在传染病数据管理中的基本作用.
- 详细说明IDO的新病原体特定扩展的开发和范围.
- 突出在本体学模块化和可重复使用性传染病研究的进步.
主要方法:
- 采用"中枢和分支"方法来生成病原体特定的本体学扩展.
- 病毒传染病本体学 (VIDO),细菌传染病本体学 (BIDO),菌传染病本体学 (MIDO) 和寄生虫传染病本体学 (PIDO) 的发展.
主要成果:
- 传染病本体学 (IDO) 及其核心组成部分的介绍.
- 关于IDO及其新扩展的范围,主要类别和关系的详细报告.
- 展示IDO扩展在组织传染病数据中的应用和实用性.
结论:
- 创建病原体特定的本体学促进了IDO生态系统中的模块化和可重复使用性.
- 未来的工作将涉及完善现有的本体论,开发新的扩展,并创建应用本体论.
- 这些努力与标准化生物和生物医学术语的更广泛目标保持一致,以改善数据共享,质量和分析.
更多相关视频
09:37Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
9.6K
09:34Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
33.4K
相关概念视频
01:26Principles of Disease Surveillance
48
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
48
01:17Classification of Illness
7.2K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.2K
01:20Infection
6.5K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
6.5K
01:45ER Retrieval Pathway
3.6K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
3.6K
02:40The Tree of Life - Bacteria, Archaea, Eukaryotes
31.7K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
31.7K
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
3.9K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
3.9K