微生物衍生P=S和P=Se键形成
Connor L Trotter1, Yuta Era1, Rory Gordon1,2
1Institute of Quantitative Biology, Biochemistry and Biotechnology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FF, U.K.
JACS Au
|May 2, 2025
概括
这项研究表明,细菌可以通过中央硫代谢产生-硫键. 这种微生物过程也用于化学合成中的-键形成.
科学领域:
- 微生物生物技术 微生物生物技术
- 合成生物学 合成生物学
- 化学合成 化学合成
背景情况:
- 微生物代谢提供可持续的合成试剂,但其在化学合成中的直接应用是有限的.
- 现有的合成生物学工具专注于控制代谢化学,而不是合成代谢物的利用.
研究的目的:
- 通过中央硫代谢来研究微生物-硫 (P=S) 键的形成.
- 探索微生物代谢物在化学合成中用于- (P=Se) 键形成的应用.
主要方法:
- 在各种细菌中使用中心硫代谢和非酶化学在体内研究P=S键的形成.
- 在化学合成中用于P=Se键形成的微生物代谢物.
主要成果:
- 证明各种细菌可以通过它们的中心硫代谢进行P=S键形成 (Ph3P到Ph3PS).
- 在化学合成中成功地应用了这种微生物过程来形成P=Se键 (Ph3PSe).
- 这代表了对微生物P=S键形成的第一个生化和遗传研究.
结论:
- 微生物的硫代谢可以用来形成P=S和P=Se键.
- 这项工作扩大了微生物代谢物在化学合成和合成生物学中的实用性.
更多相关视频
08:46Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
7.7K
07:14Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
2.5K
相关概念视频
Phosphodiester Linkages
97.8K
Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
97.8K
The Phosphorus Cycle
36.1K
Unlike carbon, water, and nitrogen, phosphorus is not present in the atmosphere as a gas. Instead, most phosphorus in the ecosystem exists as compounds, such as phosphate ions (PO43-), found in soil, water, sediment and rocks. Phosphorus is often a limiting nutrient (i.e., in short supply). Consequently, phosphorus is added to most agricultural fertilizers, which can cause environmental problems related to runoff in aquatic ecosystems.
36.1K
Hybridization of Atomic Orbitals II
31.0K
sp3d and sp3d 2 Hybridization
31.0K
Molecular Geometry and Dipole Moments
12.3K
The VSEPR theory can be used to determine the electron pair geometries and molecular structures as follows:
12.3K
The Sulfur Cycle
43.3K
Sulfur, an important element in the chemical makeup of proteins, is recycled through the atmosphere and aquatic and terrestrial environments. Found in the atmosphere as sulfur dioxide (SO2), sulfur is released by decaying organisms, weathered rocks, geothermal vents, volcanos, and burning fossil fuels. It is deposited into the ecosystem, cycled through the biotic community, and either released back into the atmosphere as gas or deposited in marine sediment for long-term storage and eventual...
43.3K
Preparation and Reactions of Sulfides
4.6K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
4.6K
