脂蛋白胆固醇比率和美国成年人的心血管疾病风险:一个横截面研究
Xiuming Yang1, Qiuyun Chen1, Qingyu Zhang2
1Department of Cardiology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China.
Frontiers in nutrition
|May 2, 2025
概括
非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比率 (NHHR) 显示了与心血管疾病 (CVD) 风险的J形关联. 这种脂质代谢指标可能有助于识别患心血管疾病高风险的人.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 生物标志物 生物标志物
背景情况:
- 非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比率 (NHHR) 是评估脂质代谢的新型指标.
- 了解NHHR和心血管疾病 (CVD) 之间的关系对于风险分层至关重要.
研究的目的:
- 调查NHHR与心血管疾病患病率之间的关联.
- 为了确定NHHR对心血管疾病风险的潜在值影响.
主要方法:
- 利用了涉及11471名参与者的横截面研究 (NHANES,2003-2016) 的数据.
- 采用多变量逻辑回归分析 (LRA) 和受限立方线 (RCS) 分析来评估NHHR-CVD关联.
- 使用两段零碎LR模型进行值分析以确定值效应.
主要成果:
- 在NHHR和心血管疾病风险之间观察到非线性J形关联.
- 确定了一个显著的值效应,触点在NHHR = 2.82.2.
- 超过值1个单位的NHHR增加与21%的心血管疾病可能性增加有关 (OR = 1.21,95%CI = 1.10-1.34).
结论:
- 该NHHR显示了与心血管疾病患病率的J形关联,表明其作为高风险心血管疾病人群的新标志物的潜力.
- 这些发现表明,NHHR的临界值超过了,心血管疾病风险显著增加.
- 建议进行进一步的纵向队列研究来验证这些发现.
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