孕产妇的铁水平和与妊娠期糖尿病的关联:系统性审查和元分析
Jinguang Wang1, Zhen-Yu Chen1, Jian Shen1
1Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenhe District, Shenyang 110016, China.
Journal of nutrition and metabolism
|May 2, 2025
概括
高水平的费里和铁会增加妊娠期糖尿病的风险. 低的总结合铁能力也与更高的GDM风险有关. 这一元分析突出了与GDM相关的关键铁标记.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 孕期糖尿病 (GDM) 是一个重要的妊娠并发症.
- 铁代谢在各种生理过程中发挥作用,可能会影响GDM风险.
研究的目的:
- 系统地审查和评估铁含量与患妊娠糖尿病的风险之间的关联.
- 为了研究费里和GDM风险之间的剂量反应关系.
主要方法:
- 对1995年1月至2023年1月期间发表的相关文章进行系统的文献搜索.
- 使用随机效应的元分析来总结相对风险 (RR) 和标准化平均差异.
- 剂量反应分析,以探索费里暴露和GDM风险的线性和非线性趋势.
主要成果:
- 分析包括30项血清铁素 (SF),18项血清铁 (SI),4项血清转激素受体 (sTfR),5项总铁结合能力 (TIBC) 和4项转激素 (TRF) 的研究.
- 最高的SF度与显著增加的GDM风险相关 (调整后OR:1.82;95%CI:1.54-2.14)
- 在SF中增加5μg/L与GDM风险增加2.66%相关,线性和非线性趋势都表明在SF水平较高时风险增加.
结论:
- 高水平的费里与妊娠期糖尿病的风险增加显著相关.
- 高铁含量和低总铁结合能力也被确定为GDM的危险因素.
- 这些发现强调了在怀孕期间监测铁状况对于预防GDM的重要性.
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