相关实验视频
Updated: May 9, 2025

05:37
An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
1.9K
深度神经网络基础竞争风险在预测心力衰竭患者的存活率
Solmaz Norouzi1, Ebrahim Hajizadeh1, Mohammad Asghari Jafarabadi2,3
1Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Journal of diabetes and metabolic disorders
|May 2, 2025
概括
深度神经网络竞争风险 (DNNCR) 模型比随机生存森林 (RSF) 模型更好地预测心力衰竭 (HF) 患者的生存结果. 这种人工智能方法有助于识别高风险个体,以定制治疗策略.
科学领域:
- 心脏病学 心脏病学
- 生物统计学 生物统计学
- 人工智能的人工智能
背景情况:
- 心力衰竭 (HF) 存在复杂的预后挑战,原因是存在竞争的风险,如HF特异性死亡率和其他死亡原因.
- 准确预测时间到事件的结果对于高频患者的有效管理至关重要.
研究的目的:
- 将深度神经网络竞争风险 (DNNCR) 模型的预测性能与随机生存森林 (RSF) 模型进行比较,以在HF患者中预测时间到事件的结果.
- 评估模型在心力衰竭生存分析中处理竞争风险的能力.
主要方法:
- 对435名心力衰竭患者进行了回顾性分析,随访期为5年.
- 应用深度神经网络竞争风险 (DNNCR) 和随机生存森林 (RSF) 模型来分析具有竞争风险的生存数据.
- 使用C指数和综合障碍评分 (IBS) 评估模型性能.
主要成果:
- 与RSF相比,DNNCR模型的预测性能优于RSF模型,高C指数值表明,HF特异性死亡和其他死亡原因的C指数值更高.
- DNNCR的C指数为HF的0.65和其他原因的0.63,超过RSF的C指数,分别为0.65和0.61.
- 使用IBS进行的校准分析显示,DNNCR模型的性能优越,IBS值为HF的0.16,其他原因为0.18.
结论:
- 在预测心力衰竭患者的生存结果方面,DNNCR模型显著优于RSF模型,特别是在处理竞争性风险时.
- 提高预测准确度有助于更好地识别高风险患者,从而实现个性化治疗策略.
- 未来的研究应该集中在不同的数据集上,以提高DNNCR的性能和临床整合.
相关概念视频
Pathophysiology of Heart Failure
1.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.4K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
302
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
302
Heart Failure Drugs: β-Blockers
259
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
259

