在老年男性中,尼沃卢马布治疗的次要多种皮肤不良反应
Divya Bhatia1, Ekta Gupta1, Anupama Bains1
1Dermatology, All India Institute of Medical Sciences, Jodhpur, IND.
Cureus
|May 2, 2025
概括
尼沃卢马布是晚期黑色素瘤的PD-1抑制剂,可以引起皮肤副作用,如斯威特综合征. 用达普松治疗和降低尼沃卢马布剂量可以解决该综合征,尽管脱色素持续存在.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 尼沃卢马布是一种针对PD-1的免疫检查点抑制剂,用于晚期黑色素瘤.
- 皮肤不良事件在PD-1抑制剂中很常见.
- 这一案例突出了对尼沃卢马布治疗的特定皮肤反应.
研究的目的:
- 报告一例转移性黑色素瘤患者在开始服用尼沃卢马布后出现多种皮肤副作用的病例.
- 描述这些副作用的临床表现,诊断和管理.
主要方法:
- 一名患有转移性黑色素瘤的患者接受了nivolumab的治疗.
- 临床观察发生皮肤副作用,包括白风样脱色,状突发症和Sweet综合征.
- 治疗包括停止尼沃卢马布,达普,局部莫梅和减少剂量.
主要成果:
- 患者出现了白风状的色素丧失,状突发症和斯威特综合征.
- 在用达普松和局部用莫梅治疗四周内,斯威特综合征完全消失.
- 降低20%的尼沃卢马布剂量并没有导致苏伊特综合征的复发,但白风状的色素丧失仍然存在.
结论:
- 尼沃卢马布可以诱导各种皮肤副作用,包括斯威特综合征,状皮疹喷发和白风样脱色.
- 在这种情况下,斯威特综合征可以通过达普松和局部皮质类固醇治疗,并可能通过对尼沃卢马布剂量修改来控制.
- 像白风一样的色素丧失可能是nivolumab治疗的持续副作用.
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