生殖尿路癌症中的免疫疗法毒性:临床医生的见解和挑战
Chiara Mercinelli1,2, Chiara Carli3, Rosanna Di Vita3
1Vita-Salute San Raffaele University.
Current opinion in urology
|May 2, 2025
概括
免疫检查点抑制剂 (ICI) 改变了生殖尿道癌症的治疗,但导致了与免疫相关的不良事件 (irAEs). 了解和管理这些毒性对于安全有效的免疫疗法使用至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生殖尿道癌症的治疗方法
背景情况:
- 免疫疗法,特别是免疫检查点抑制剂 (ICI),已经彻底改变了泌尿生殖系统癌症的治疗.
- 现在ICI是膀和癌的标准护理,影响局部和转移性疾病.
研究的目的:
- 审查ICI在生殖尿路癌症中的安全性.
- 针对免疫相关不良事件 (irAEs) 的发生率,机制和管理.
主要方法:
- 关于ICI在生殖尿路恶性瘤中的安全性最近研究的文献综述.
- 在不同器官系统和治疗环境中分析irAEs.
主要成果:
- ICI诱导了一系列影响多个器官系统的irAEs,严重程度各不相同.
- 组合疗法 (例如,PD-1/PD-L1与CTLA-4或化疗) 可能会增加irrAE的风险.
- 某些患者亚组和那些患有自身免疫疾病的人可能面临毒性增加.
结论:
- 持续监测和迅速管理irAEs对于安全的免疫疗法至关重要.
- 需要进一步的研究来阐明irAE机制并优化治疗耐受性.
- 临床医生早期识别irAEs对于患者的治疗结果至关重要.
更多相关视频
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
12.0K
06:38A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
13.5K
相关概念视频
Tumor Immunotherapy
397
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
397
Cancer Therapies
7.4K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.4K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Cancer Vaccines
237
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
237
