在COVID-19之后的长期认知功能:随着时间的推移可以忽略的神经心理变化
Dook W Koch1,2, Simona Klinkhammer3,4, Anouk Verveen1,5
1Department of Medical Psychology, Amsterdam UMC Location AMC, Amsterdam, The Netherlands.
The Clinical neuropsychologist
|May 2, 2025
概括
大多数COVID-19幸存者没有显著的长期认知缺陷. 神经心理功能在2.5年内保持稳定,只有少数人在感染后经历了持续的,非特定的认知问题.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 认知心理学 认知心理学
背景情况:
- 在一小部分住院COVID-19患者中观察到认知障碍.
- 评估COVID-19幸存者的长期认知变化的纵向研究是有限的.
- 了解SARS-CoV-2感染后认知缺陷的持续和演变至关重要.
研究的目的:
- 调查COVID-19幸存者的客观认知功能中的存在和长期变化.
- 在住院后大约1年和2.5年评估认知表现.
- 确定影响这一群体认知结果的潜在因素.
主要方法:
- 46名COVID-19幸存者在两个时间点 (感染后1年和2.5年) 接受了神经心理评估.
- 评估包括记忆,注意力,执行功能,处理速度和语言,使用14个子测试.
- 用年龄,性别和教育调整的T-score来识别认知缺陷 (T ≤ 35).
主要成果:
- 平均神经心理性能在感染后的1年和2.5年都保持在正常范围内.
- 客观认知缺陷存在于0-22%的个体中,没有一致的受影响领域.
- 语音流性随着时间的推移而有所改善 (p<.001),而其他认知领域保持稳定,无论伴随疾病或ICU入院情况如何.
结论:
- 大多数COVID-19幸存者在感染多年后没有表现出一致的客观认知缺陷或主要认知障碍.
- 神经心理功能在2.5年的随访期内通常保持稳定.
- 需要进行更大的纵向研究来定义特定的COVID-19相关的认知表型和潜在的干预措施.
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