自然产品作为永恒的疗法 - - 解开自然宝藏
Tamara Balsiger1, Robin Teufel2, Eliane Garo3
1Department of Pharmaceutical Sciences, University of Basel, CH-4056 Basel. tamara.balsiger@unibas.ch.
自然产品对于药物发现至关重要. 一项新的战略结合了对2500多种植物提取物的选与基于HPLC的活性分析,以有效地从复杂混合物中分离活性化合物.
科学领域:
- 自然产品化学 自然产品化学
- 药物发现 药物发现 药物发现
- 药理学 药理学是指药理学的学科.
背景情况:
- 自然产品是批准药物的重要来源.
- 从复杂的天然提取物中分离活性化合物在药物发现中是一个重大挑战.
研究的目的:
- 开发和实施天然产品药物发现的有效策略.
- 为了克服将活性化合物从大量自然产品提取物库中分离出来的瓶.
主要方法:
- 选一个内部的原始植物提取物库,超过2500个样本.
- 使用基于高性能液态染色学 (HPLC) 的活性分析来识别化合物.
主要成果:
- 开发的工作流允许对广泛的自然产品库进行有效选.
- 在多个天然产品药物发现项目中成功应用该策略.
结论:
- 大规模查和HPLC活动概况的结合方法是天然产品药物发现的强有力的方法.
- 这一战略有效地解决了与分离生物活性天然产品相关的挑战.
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