瘤微环境调制创新结合性癌症治疗通过一个多功能石墨烯氧化物纳米系统
Chuxin Cai1, Qingming Zhang2, Junqiu Ye1
1State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. dydszyzf@163.com.
Biomaterials science
|May 2, 2025
概括
石墨烯氧化物 (GO) 纳米材料与瘤微环境 (TME) 相互作用,以克服癌症治疗的挑战. 这次审查探讨了GO的 GO.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 瘤微环境 (TME) 对有效的癌症治疗构成重大障碍.
- TME包括多种细胞组件,细胞外基质和信号分子,促进瘤生长和转移.
- 氧化石墨烯 (GO) 具有独特的特性,使其成为癌症治疗的有前途材料.
研究的目的:
- 审查石墨烯氧化物 (GO) 与瘤微环境 (TME) 之间的多方面的相互作用.
- 突出基于GO的策略在癌症治疗中调节TME的潜力.
- 探索可触发TME的药物输送系统,利用GO进行增强型瘤治疗.
主要方法:
- 对调查GO与TME组件相互作用的研究的文献综述.
- 对TME调制相关的GO的特性 (表面积,结构,电子光子特性) 的分析.
- 综合了关于GO在生物分子捕获,催化,癌症干细胞向和TME内的免疫反应中的作用的发现.
主要成果:
- GO可以与TME的各种维度相互作用和调节,包括细胞和分子组件.
- 基于GO的材料显示出捕获生物分子,催化反应,向癌症干细胞和引起免疫反应的潜力.
- 结合治疗策略利用GO的TME相互作用提供了克服治疗耐药性的创新方法.
结论:
- 石墨烯氧化物 (GO) 纳米材料为与瘤微环境 (TME) 相互作用和操纵提供了多功能平台.
- 用GO调节TME对于开发先进的组合性癌症疗法具有显著的前景.
- 对基于GO的纳米药物的进一步研究可以促进更合理,更有效的瘤治疗策略.
更多相关视频
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.1K
10:13A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
Published on: November 7, 2015
11.1K
相关概念视频
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
01:27Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K