相关实验视频

Updated: May 9, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

巨细胞动脉炎与心血管疾病风险增加有关吗? 一个元分析

Hritvik Jain¹, Maryam Shahzad², Nandan Patel¹

¹From the Department of Cardiology, All India Institute of Medical Sciences (AIIMS), Jodhpur, India.

Cardiology in review

|May 2, 2025

概括

巨细胞动脉炎 (GCA) 显著增加心血管风险. 患有GCA的患者面临心肌梗塞,中风和外周动脉疾病的更高风险,这凸显了早期风险管理的必要性.

科学领域:

类风湿病学类风湿病学
心脏病学心脏病学
流行病学流行病学

背景情况:

巨细胞动脉炎 (GCA) 是影响50岁以上个体的主要血管炎.
GCA与不良心血管事件之间的关联仍在争论中,现有文献中存在相互矛盾的证据.

研究的目的:

在被诊断患有GCA的患者中进行元分析,调查心肌梗塞 (MI),中风和外周动脉疾病 (PAD) 的风险.

主要方法:

在主要数据库 (PubMed,EMBASE,Google Scholar,SCOPUS,Web of Science) 进行了系统的文献搜索,截至2024年11月1日.
来自10项研究的数据,包括518,402名参与者 (28,707名GCA),使用RevMan 5.4.4中的随机效应模型进行了分析.
使用95%置信区间 (CI) 计算聚合危险比率 (HR),以评估心血管风险.

主要成果:

GCA显著与心脏病发作风险增加有关 (HR,1.74;95% CI,1.34-2.25).
在GCA患者中观察到中风的风险增加 (HR, 1.43; 95% CI, 1.33-1.54).
在GCA患者中,PAD风险显著增加 (HR,1.98;95% CI,1.53-2.57).

结论:

这一元分析证实,GCA患者患主要心血管不良事件的风险明显更高,包括心脏病发作,中风和PAD.
这些发现强调了主动评估和管理GCA患者的心血管风险的重要性.
建议进行进一步的前性研究,以验证这些心血管风险的增加,并为临床实践提供信息.

关键词:

心血管事件的发生.巨细胞动脉炎的发生心肌梗塞的心脏病发作周围动脉疾病周围动脉疾病一次性中风中风中风中风中风

更多相关视频

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Published on: January 13, 2012

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...