常见疫苗接种的角膜并发症
Kartik Gannamaneni1,2, Shahzad I Mian2
1Indiana University School of Medicine, Indianapolis, Indiana.
Current opinion in ophthalmology
|May 2, 2025
概括
接种针对SARS-CoV-2,Varicella-Zoster和流感的疫苗很少导致角膜并发症,如角膜炎或移植排斥. 临床医生应评估患者的风险因素,并监测副作用.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 角膜并发症,包括角膜炎和移植排斥,是接种疫苗后的潜在问题.
- 针对SARS-CoV-2,疹和流感的疫苗被广泛使用,因此需要了解它们对眼部的副作用.
研究的目的:
- 审查和评估与常见疫苗接种相关的角膜并发症的现有文献.
- 为了特别评估SARS-CoV-2,疹-Zoster和流感疫苗接种后角膜炎和角膜移植排斥的风险.
主要方法:
- 对案例系列,报告和基于人口的研究的文献综述.
- 对已记录的角膜并发症和疫苗接种后的移植拒绝率的分析.
主要成果:
- 在接种疫苗后报告了罕见的角膜炎/疹病毒再激活和角膜移植排斥病例.
- 人口研究表明,在COVID-19和 varicella-zoster疫苗下,疹病毒角膜炎和眼科炎复发的风险略高,特别是在有风险的人群中.
- 角膜移植排斥率总体保持稳定,在透角质形成和高风险患者中发现的发生率较高.
结论:
- 接种疫苗的好处明显超过角膜并发症的风险.
- 识别和管理患者特异性风险因素对于知情咨询和疫苗接种后护理至关重要.
- 在易受感染的患者中,可能需要考虑增加类固醇的使用,并对角质炎或移植排斥进行警的随访.
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