抗逆转录病毒药物和同时治疗的抗逆转录病毒药物之间的药物药物相互作用的减少,在与艾滋病毒-1感染者过渡到比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺胺的老年人中
Leonardo Calza1, Maddalena Giglia1, Alberto Zuppiroli1
1Department of Medical and Surgical Sciences, Unit of Infectious Diseases.
The new microbiologica
|May 2, 2025
概括
在艾滋病毒感染的老年人中,转换为比克特格拉维尔/埃姆特里西塔宾/特诺福维尔阿拉芬胺 (BIC/FTC/TAF) 显著减少了药物相互作用. 这种疗法保持了高的病毒抑制,并且在这个人群中耐受良好.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 艾滋病毒感染的老年人往往有复杂的药物治疗方案.
- 药物相互作用 (DDI) 在这个人群中是一个重大问题.
- 关于新型抗逆转录病毒疗法在老年人中的有效性和安全性的数据有限.
研究的目的:
- 评估转换为比克特格拉维尔/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) 对60岁及以上艾滋病毒感染者 (PLWH) 病毒性抑制患者的DDI的影响.
- 在这个人口群体中评估BIC/FTC/TAF的病毒学有效性和耐受性.
主要方法:
- 对109名年龄≥60岁的PLWH进行了回顾性队列研究,他们转换为BIC/FTC/TAF.
- 在切换之前和之后分析潜在的DDI.
- 在12个月后评估HIVRNA水平和治疗中断率.
主要成果:
- 在切换到BIC/FTC/TAF后,观察到潜在的DDI显著减少 (从139到18,-87%;p<0.001).
- 中位数DDI得分下降了78% (p<0.001).
- 病毒学疗效很高,92.7%的患者在12个月内达到HIVRNA<20拷贝/毫升.
结论:
- 切换到BIC/FTC/TAF有效地减少了老年,病毒学上受抑制的PLWH中DDI.
- 该疗法在这个人群中显示出高效率和良好的耐受性.
- BIC/FTC/TAF是一种有价值的选择,可以简化艾滋病毒感染的老年人治疗和管理多药.
相关概念视频
Retrovirus Life Cycles
45.3K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.3K
Factors Affecting Drug Response: Overview
1.6K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.6K
Combined Effects of Drugs: Synergism
3.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.6K
Factors Affecting Protein-Drug Binding: Drug Interactions
59
Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
59
Pulmonary Tuberculosis I
198
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
198
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
991
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
991


