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绝对淋巴细胞计数轨迹预测严重受伤患者的临床结果

Lena-Marie Reichardt¹, Bianca Hindelang¹, Lönna Süberkrüb¹

¹Translational and Experimental Trauma Research, Department of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Ulm, Ulm, Germany.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

|May 2, 2025

概括

绝对淋巴细胞计数 (ALC) 的动态变化可以预测创伤患者的结果. 在48小时内监测ALC有助于识别高风险个体,以便做出更好的临床决策.

科学领域:

创伤重症监护中心的重症监护中心.
免疫学免疫学免疫学
临床生物标志物临床生物标志物

背景情况:

淋巴缺血与创伤患者的不良结果有关.
没有确立的免疫监测方法可以识别有风险的创伤患者.
绝对淋巴细胞计数 (ALC) 是一个有前途的生物标志物,用于ICU的临床决策.

研究的目的:

在严重受伤的患者中检查ALC的时间模式.
为了将ALC动态与临床结果相关联.
评估ALC作为创伤护理中的潜在免疫监测工具.

主要方法:

纳入了38名严重受伤的患者 (ISS ≥18).
血液样本采集在入院,8,24,48小时,和5,10天.
根据48小时的动态ALC,患者被分为四组:持久性淋巴缺血 (PL),快速下降 (RD),缓慢上升 (SR) 和正常波动 (NF).
评估结果:身体表现,住院死亡率,ICU停留时间 (LOS) 和多器官功能障碍综合征 (MODS).

主要成果:

与对照组相比,所有患者的ALC都减少了,到第10天恢复趋势明显.
持久性淋巴缺血 (PL) 和快速下降 (RD) 的ALC与不利的结果有关.
PL和RD组的住院死亡率更高,ICU LOS更长,MODS发病率增加.

结论:

在48小时内动态ALC监测是严重受伤患者的成本效益和可实施的方法.
通过ALC动态,可以早期识别高风险创伤患者.
这有助于在重症监护病房做出明智的临床决策.

关键词:

免疫监测免疫监测免疫抑制是一种免疫抑制.淋巴细胞计数淋巴细胞计数淋巴细胞减少症 (Lymphopenia) 是一种严重受伤的患者严重受伤.

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