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宫外库希综合征是否常常与小细胞肺癌 (SCLC) 有关? 文学和ACTH表达在切除的SCLC中的批判性审查

Ayako Ura¹, Elisa Moser¹, Matthias Evert²

¹Department of Pathology, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany.

Endocrine pathology

|May 2, 2025

概括

这项研究质疑小细胞肺癌 (SCLC) 和宫外库希综合征 (ECS) 之间的联系. 研究表明神经内分泌瘤 (NETs) 是主要原因,对SCLC参与ECS的证据有限.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
病理学病理学病理学

背景情况:

肺外皮库希综合征 (ECS) 经常与神经内分泌瘤 (NETs) 和小细胞肺癌 (SCLCs) 相关.
然而,肺外ECS主要与NET相关,罕见的发生与神经内分泌癌 (NEC) 相关.
作为ECS的原因,SCLC的频率需要进行批判性评估.

研究的目的:

批判性地审查将SCLC与ECS (ECS-SCLC) 关联的文献.
在切除的SCLC和肺 NET中进行ACTH表达的免疫组织化学分析.
确定SCLC对ECS发展的实际贡献.

主要方法:

对1952年至2023年的ECS-SCLC病例进行了全面的文献搜索.
在报告的ECS-SCLC病例中确认SCLC诊断的组织学图像质量评估.
在155个SCLC和158个肺 NET样本中对ACTH表达的免疫组合化学分析.

主要成果:

文献审查表明,90%报告的ECS-SCLC病例缺乏足够的组织学确认.
在具有可用的组织学病例中,90%被重新分类为可能的NET,只有2个被认为是SCLC兼容的.
免疫组织化学检测显示,在3%的SCLC (没有ECS) 和39%的肺 NET 中,ACTH产生NET中3%与ECS相关.

结论:

现有的文献提供了有限的证据支持SCLC作为ECS的原因.
大多数报告的ECS-SCLC病例缺乏可靠的诊断证据.
肺 NET 与 SCLC 相比,更经常与 ACTH 生产和 ECS 相关.

关键词:

这就是ACTHTH ACTH.宫外丘辛综合征宫外丘辛综合征肺肺肺肺肺肺在SCLC中,SCLC是最重要的.

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