对高发育年龄妇女体外受精中hCG和双触发协议的比较分析:基于倾向性得分匹配的单中心回顾性队列研究
Minghui Yuan1, Xuemei Lv2, Yuying Yuan3
1Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Archives of gynecology and obstetrics
|May 2, 2025
概括
对于接受试管婴儿的老年妇女来说,人类胆管性腺激素 (hCG) 和双触发协议都显示了类似的活产率. 然而,双触发协议可能在受精和活产时间方面提供优势.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
背景情况:
- 辅助生殖技术对于管理母亲年龄较高的妇女的不孕症至关重要.
- 优化排卵诱导和质期支持是提高试管婴儿成功率的关键.
研究的目的:
- 在35岁及以上的女性体外受精 (IVF) 中,比较人类胆管性淋巴激素 (hCG) 触发剂与双触发剂协议 (淋巴激素释放激素激动剂[GnRH-a]和hCG) 在体外受精 (IVF) 的疗效.
- 评估累积活产率 (CLBR) 和活产时间 (TTLB) 作为主要结果.
主要方法:
- 一项对801名年龄≥35岁的女性进行的回顾性研究,她们正在接受第一次试管婴儿周期.
- 使用双触发协议的115名妇女和使用hCG触发协议的686名妇女之间的比较.
- 倾向性得分匹配被用于控制混因素,以CLBR和TTLB作为主要终点.
主要成果:
- 双触发 (26.09%) 和hCG (29.86%) 组 (P=0.44) 之间没有观察到累积活产率 (CLBR) 的显著差异.
- 生产时间 (TTLB) 在两组之间也相似 (9.60 vs 10.14 个月,P=0.72).
- 卡普兰-梅尔分析和考克斯的比例危险建模证实了两种协议之间的可比的CLBRs.
结论:
- 虽然CLBR和TTLB是相似的,但由于潜在的更高的受精率,双触发协议可能是有利的.
- 进一步的研究可以探索特定的子组或额外的结果,以充分阐明双触发协议在老年妇女的好处.
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