氧化应激和自闭症中的动态醇/二硫化物恒温:专注于早期儿童
Halenur Teke1, Senay Balci2, Salim Neselioglu3
1Department of Child and Adolescent Psychiatry, Medical Faculty, Mersin University, Ankara, Turkey. drhalenurteke@gmail.com.
Journal of molecular neuroscience : MN
|May 2, 2025
概括
氧化应激 (OS) 生物标志物,包括新的动态醇/二硫化物稳态 (DTDH) 测量,在患有自闭症谱系障碍 (ASD) 的学龄前儿童中没有显著差异. 年龄可能是OS相关自闭症变化的关键因素,这需要进一步的年龄分层研究.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 发育儿科 发育儿科
背景情况:
- 氧化应激 (OS) 是自闭症谱系障碍 (ASD) 发病的一个被提议因素.
- 动态醇/二硫化物稳定性 (DTDH) 是OS的一个新型生物标志物.
- 了解儿童早期自闭症障碍的操作系统至关重要.
研究的目的:
- 评估ASD学龄前儿童的血DTDH和经典OS生物标志物.
- 评估OS标志物与自闭症严重程度之间的关系.
- 调查ASD早期发展阶段的OS动态.
主要方法:
- 在49名患有自闭症儿童和31名对照儿童 (2-6岁) 中,比较了OS生物标志物 (DTDH,TOS,TAS,OSI,Glutathione,GPx).
- 利用血液样本的自动光谱测量分析.
- 使用CARS和CGI-S尺度评估自闭症严重程度.
主要成果:
- 在ASD和对照组之间,在DTDH或经典OS标记上没有统计学上显著的差异.
- 在OS生物标志物和自闭症严重程度之间没有发现显著的关联.
- 操作系统标志物显示了并行变化,但缺乏群体差异化.
结论:
- 血OS标记物,包括DTDH,在患有自闭症的学龄前儿童中没有显著差异.
- 年龄似乎是影响ASD的OS变化的关键因素.
- 需要进一步的年龄分层研究来澄清OS在ASD中的作用.
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