抑郁症使癌症死亡率增加23-83%:对五种主要癌症类型的65项研究进行了元分析
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Zoltan Ungvari1,2,3,4,5, Mónika Fekete6,7, Annamaria Buda6,7,8
1Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
癌症患者的抑郁症显著增加了癌症特异性死亡风险. 将心理健康查和干预整合到瘤治疗中,对于改善生存结果至关重要.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 抑郁症是癌症患者常见的并发症,经常被忽视.
- 心理压力可能会对癌症的结果产生负面影响,但其对生存的影响尚未完全理解.
研究的目的:
- 评估抑郁症诊断后癌症诊断和癌症特异性和全因死亡率之间的关联.
- 通过元分析,分析主要癌症类型之间的这种关联.
主要方法:
- 在PubMed,科学网,谷歌学者和科克兰图书馆的系统文献搜索.
- 包括65项评估抑郁症和报告死亡风险比率的队列研究.
- 随机效应的元分析,以汇集HRs,与异质性和出版偏差评估.
主要成果:
- 抑郁症显著增加了结直肠癌 (HR 1.83),乳腺癌 (HR 1.23),肺癌 (HR 1.59) 和前列腺癌 (HR 1.74) 的癌症特异性死亡率.
- 在混合癌症类型中,抑郁症与38%的癌症死亡率风险增加有关 (HR 1.38).
- 发现了显著的异质性 (I2 56-98%),敏感性和试验顺序分析证实了可靠的发现.
结论:
- 诊断后抑郁症与癌症特异性死亡风险大幅增加有关.
- 在瘤治疗中,急需进行常规的心理健康查和干预.
- 进一步的研究应探索机制性途径和有针对性的干预措施,以改善癌症存活率.
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