对叶酸-维生素B相互作用的新见解12
Luisa F Castillo1, Caitlyn M Pelletier1, Katarina E Heyden1
1Division of Nutritional Sciences, Cornell University, Ithaca, New York, NY, USA;
Annual review of nutrition
|May 2, 2025
概括
高摄入叶酸可能会加剧维生素B12缺乏的影响,特别是神经认知障碍. 本综述探讨了这种相互作用背后的分子机制,重点关注模型系统研究.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 代谢途径 代谢途径
背景情况:
- 叶酸和维生素B12 (B12) 对单碳代谢至关重要,对于DNA合成和氨基酸再生至关重要.
- 缺乏导致巨细胞贫血; B12 缺乏也会导致神经认知问题.
- 叶酸强化在美国很常见,增加叶酸摄入量,但也超过了一些人的上限.
研究的目的:
- 审查将高叶酸和维生素B12缺乏症联系在一起的分子机制.
- 探索高叶酸如何加剧与B12缺乏有关的神经认知和代谢问题.
- 综合模型系统研究中关于这种相互作用的发现.
主要方法:
- 文献综述侧重于分子机制.
- 在模型系统中分析研究叶酸-B12相互作用的研究.
- 综合当前关于代谢和神经认知后果的研究.
主要成果:
- 血清叶酸水平升高可能会加剧与B12缺乏相关的神经认知缺陷.
- 高叶酸,B12缺乏和改变葡萄糖平衡或后代2型糖尿病风险之间的潜在联系.
- 涉及单碳新陈代谢的分子途径也在其中.
结论:
- 叶酸和B12之间的相互作用是复杂的,其影响超出了贫血.
- 高酸摄入量需要考虑B12缺乏个体的潜在不良影响.
- 对模型系统的进一步研究对于阐明这些机制至关重要.
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