改善尾肌肉强度预测心力衰竭患者的死亡率较低
Takumi Noda1, Kentaro Kamiya2, Nobuaki Hamazaki3
1Department of Rehabilitation Sciences, Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan; Department of Cardiovascular Rehabilitation, National Cerebral and Cardiovascular Center, Suita, Japan.
Nutrition (Burbank, Los Angeles County, Calif.)
|May 2, 2025
概括
在心力衰竭 (HF) 患者心脏康复 (CR) 后改善肌肉虚弱 (动力衰弱) 与更好的运动能力有关,但不一定会降低死亡率. 持续性或新出现的动脉缩症表明死亡风险较高.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 康复医学 康复医学 康复医学
背景情况:
- 肌肉强度下降 (动力衰竭) 是心力衰竭 (HF) 患者预后不佳和身体功能下降的已知预测因素.
- 在心脏康复 (CR) 后,动脉动脉症状态的变化对HF患者的结果的影响需要进一步调查.
研究的目的:
- 调查尾肌肉疲弱 (动力衰弱) 的改善是否预测心力衰竭 (HF) 患者的更好的预后和增强的身体功能.
- 分析不同动脉动脉症 (CR前后) 和死亡率和身体功能指标之间的关联.
主要方法:
- 在基线 (出院前) 和随访 (CR后) 时评估手握和腿部强度,在607名高压患者中.
- 将患者分类为四种动脉动脉症:非动脉动脉症/非动脉动脉症,动脉动脉症/非动脉动脉症,非动脉动脉症/动脉动脉症和动脉动脉症/动脉动脉动脉症.
- 利用考克斯回归和混合效应模型分析与所有原因死亡率,6分钟步行距离和步行速度的关联.
主要成果:
- 患有持续性动脉动脉症 (基线/随访时的动脉动脉症) 和发生CR后动脉动脉症 (非动脉动脉症/动脉动脉动脉症) 的患者的死亡率明显较高.
- 没有观察到在基线发动性患者改善 (发动性/非发动性) 和那些仍然没有发动性患者之间死亡风险的显著差异.
- 改善的动力状态与增加的6分钟步行距离相关 (p = 0.004),但与步行速度无关 (p = 0.173).
结论:
- 在心脏康复治疗后持续或发展的动力衰竭与心力衰竭患者全因死亡风险增加有关.
- 经过CR后的动脉状态的改善与增强的运动能力有关,特别是6分钟的步行距离.
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