的肠-丸轴:补充Lactiplantibacillus plantarum可以改善生殖能力
Szilamér Ferenczi1, Balázs Juhász2, Barbara Végi3
1Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Hungarian Research Network, Budapest, Hungary; Institute of Genetics and Biotechnology, Department of Microbiology and Applied Biotechnology, Hungarian University of Agriculture and Life Sciences, Gödöllő, Hungary.
Poultry science
|May 2, 2025
概括
益生菌 Lactiplantibacillus plantarum SNI3 (LbSNI3) 补充剂通过增强抗氧化能力和丸功能来改善的繁殖性能. 这种益生菌为提高牲畜生产率提供了一个有希望的途径.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 生殖生物学 生殖生物学
背景情况:
- 益生菌,特别是乳酸菌,对于家禽的肠道健康和表现至关重要.
- 益生菌在雄性家禽生殖功能中的作用仍然不完全理解.
- 研究新型益生菌菌株以提高牲畜生产率至关重要.
研究的目的:
- 评估新型益生菌菌株Lactiplantibacillus plantarum SNI3 (LbSNI3) 对公生殖性能的影响.
- 评估LbSNI3对丸生理学,精子参数和的抗氧化剂状况的影响.
主要方法:
- 在7周内,口服LbSNI3 (2 × 10^7 CFU/动物/天) 或载体给成年.
- 每周测量射精量,精子度,运动性和水平.
- 试验后分析丸体重,组织学,基因表达 (精子生成,氧化应激,类固醇生成) 和抗氧化剂标记 (TAC,SOD,MDA).
主要成果:
- 施用LbSNI3显著增加了射精量,精子度和透孔数量,改善了生殖指数.
- 在接受LbSNI3治疗的公中,丸大小,精卵管区域和光线都得到了增强.
- LbSNI3增强了丸的抗氧化能力 (增加了SOD,总抗氧化活性;减少了MDA) 和上调关键基因 (Gpx1, Sepw1, Dio2, Birc5, Rec8).
结论:
- 口服LbSNI3补充剂可以增强丸抗氧化剂防御机制,从而改善的生殖指数.
- 益生菌的代谢物g-glutamyl-glutamate可能通过谷氨循环加强丸的抗氧化防御.
- 通过肠-丸轴,LbSNI3显示了提高家禽生产力的潜力.
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