相关实验视频

Updated: May 20, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

针对原发性和复发性HPV相关的口腔关癌的质子疗法

Arnaud Beddok¹, Aron Popovtzer², Valentin Calugaru³

¹Department of Radiation Oncology, Institut Godinot, Reims, France; Université de Reims Champagne-Ardenne, CRESTIC, Reims, France; PET Research Center, Yale School of Medicine, New Haven, CT, USA.

|May 2, 2025

概括

质子疗法 (PT) 对治疗与人类乳头瘤病毒 (HPV) 相关的口腔支状细胞癌 (OPSCC) 有望,提供高局部区域控制,副作用比IMRT少. PT也可能受益于复发性OPSCC的再辐射.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
头部和部癌症头部和部癌症

背景情况:

在欧洲和美国,与人类乳头瘤病毒 (HPV) 相关的口腔状细胞癌 (OPSCC) 发病率不断上升.
目前的治疗方法及其相关的毒性.
对与HPV相关的OPSCC.需要有效和少有毒的治疗选择.

研究的目的:

综述和总结质子疗法 (PT) 在治疗与HPV相关的OPSCC中的潜在作用.
为了比较PT与强度调节放射治疗 (IMRT) 的疗效和毒性.
探索PT在复发性OPSCC的再辐射中的实用性.

主要方法:

从PubMed,其他学术来源和正在进行的研究中对数据进行系统审查.
对HPV阳性细胞的PT放射敏感化实验室研究的分析.
临床经验和随机试验数据 (NCT01893307) 的综述,比较PT和IMRT.
检查OPSCC中的故障模式和PT的再辐射结果.

主要成果:

在实验室中,PT证明了HPV阳性细胞的放射敏感化.
临床数据显示,与HPV相关的OPSCC相关的PT具有较高的局部区域控制 (LRC) 率 (88.6-97%).
与IMRT相比,PT显著降低了诸如口症 (12.5%) 和大脑亡 (2.3%) 等副作用.
一项随机试验证实PT与IMRT在瘤控制方面不劣,食管依赖性减少 (28%与42%相比),工作恢复改善 (71%与52%相比).
现场复发 (高达70%) 强调了需要精确的辐射输送.
在可控毒性 (11.9-36.3%) 的复发性OPSCC的再辐射中,PT显示出有希望的LRC (71.8-80.8%) 和生存率 (1年生存率:65.2-81.3%).

结论:

质子疗法是HPV相关OPSCC的可行和有效的治疗选择,提供与IMRT可比的瘤控制,毒性显著降低.
PT的精度可能有助于最大限度地减少现场复发,并改善患者的结果,包括功能恢复和生活质量.
质子疗法是复发性OPSCC中再辐射的有希望的方法,需要进一步研究和整合到治疗方案中.

关键词:

基于证据的医学是基于证据的医学.头部和部状细胞癌瘤人类人类人类人类人类乳头瘤病毒的病毒质子疗法是一种质子疗法.放射治疗疗法放射治疗疗法再辐射辐射是一种反辐射.

更多相关视频

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

相关概念视频

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...