在两种重要的皮肤微生物群物种的明显稳定性背后,存在着物种内部的动态
Jacob S Baker1, Evan Qu1, Christopher P Mancuso1
1Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell host & microbe
|May 2, 2025
概括
人的面部皮肤是独一无二的微生物菌株群落. 昆虫细菌菌株是稳定的,而Staphylococcus epidermidis菌株是动态的,为微生物组治疗开发提供了洞察力.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 人类微生物组 人类微生物组
背景情况:
- 成年人面部皮肤微生物组在物种层面上表现出相似性,但在菌株层面上表现出独特的多样性.
- 了解菌株动态对于开发有针对性的微生物群疗法至关重要.
研究的目的:
- 重建人体进化史,分析面部皮肤微生物组中的菌株动态.
- 调查Cutibacterium acnes和Staphylococcus epidermidis菌株的传播和持久性模式.
主要方法:
- 分析了4055个孤立基因组和356个元基因组.
- 重建个人进化史以揭示菌株动态.
- 调查传播事件和菌株随时间的持续性.
主要成果:
- 多个细胞通常参与微生物的传播,允许迁移.
- 家庭成员仅共享皮肤微生物菌株的一个子集.
- 斯塔菲洛科克斯 (Staphylococcus epidermidis) 菌株平均持续2年,而Cutibacterium acnes菌株更为稳定.
- 在过渡到成年人面部微生物组期间,C. acnes的殖民率更高.
结论:
- 面部皮肤微生物菌群菌株动态复杂,物种之间的稳定性各不相同.
- 过渡到成年人面部微生物组为治疗菌株移植提供了一个窗口,特别是对于C. acnes.
- 这些发现对设计有效的基于微生物组的治疗方法有影响.
相关概念视频
01:23Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
01:26Defense Mechanism Against Infection
5.8K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
5.8K
01:18Surface Membrane Barriers
768
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
768
00:58Symbiosis
27.1K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
27.1K
01:12Renewal of Skin Epidermal Stem Cells
2.4K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.4K
02:34Competition
21.3K
When organisms require the same limited resources within an environment, they may have to compete for them. Competition is a net-negative interaction. Even if two competing individuals or populations do not interact directly, the overall fitness of both competitors is lowered as a result of not having full access to the limited resource.
21.3K