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Updated: May 9, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

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通过PAF1C介导的CDK12/13激酶活性的激活对于CTD酸化和转录延长至关重要

David Lopez Martinez1, Izabela Todorovski1, Melvin Noe Gonzalez1

  • 1Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark.

Molecular cell
|May 2, 2025
PubMed
概括

研究人员发现CDK12调节RNA聚合酶II (RNAPII) 酸化,这是基因转录的一个关键步骤. 这一发现澄清了RNAPII CTD动态如何控制人类的转录周期.

关键词:
的C端域域名.美国疾病预防控制中心73 CDC73在CDK12中,CDK12就是CDK12.在CDK13中使用CDK13.在CTD中,CTD是CTD.在Paf1复合体中,的RNA聚合酶II.循环 K 循环 K 循环酸化的方法是:光化.转录 延长 延长 转录

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Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk113:15

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