关于代谢功能障碍和与酒精有关的肝病的专家共识德尔菲小组:临床实践中的机遇和挑战
Luis Antonio Diaz1, Veeral Ajmera2, Juan Pablo Arab3
1MASLD Research Center, Division of Gastroenterology and Hepatology, University of California San Diego, San Diego, California, USA; Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
概括
这个德尔菲共识为代谢功能障碍和与酒精有关的肝病 (MetALD) 提供了实际指导. 它为评估和管理MetALD提供专家建议,改善这种复杂肝病的临床护理和研究.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 与酒精有关的疾病与酒精相关的疾病
背景情况:
- 代谢功能障碍和与酒精有关的肝病 (MetALD) 是一个最近定义的疾病,具有重大临床和研究挑战.
- 目前对MetALD的定义在实际应用和科学研究中存在困难.
研究的目的:
- 为MetALD.的临床评估和管理制定实际建议.
- 通过专家的共识,解决目前在MetALD的诊断和治疗方面的挑战.
主要方法:
- 一个经过修改的Delphi过程,涉及28名国际专家进行的2次调查.
- 共识被定义为专家小组之间≥80%的一致意见.
主要成果:
- 在28份声明中达成共识,这些声明涵盖了MetALD.的评估,管理和研究需求.
- 建议包括全面的患者评估,使用酒精生物标志物 (如酸乙醇),非侵入性肝病检测和多学科管理.
- 需要进一步的研究,包括纵向研究和生物标志物的验证.
结论:
- 这个德尔菲共识为MetALD的评估和管理提供了明确,可行的建议.
- 这些发现旨在标准化临床实践,并指导未来的MetALD研究.
- 专家的共识解决了MetALD带来的独特挑战,促进了更好的患者护理.
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