接受内分泌治疗的乳腺癌患者的体重指数和临床结果:元分析和孟德尔随机化研究
Xinmiao Lin1, Hong Sun2, XiaoXia Wei2
1School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Clinical nutrition ESPEN
|May 2, 2025
概括
身体质量指数 (BMI) 通常不会影响乳腺癌内分泌治疗结果. 然而,BMI可能会影响无病存活率和阿纳斯特的副作用,在治疗计划中需要考虑.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 在接受内分泌治疗的乳腺癌患者中,身体质量指数 (BMI) 的预后作用尚未完全理解.
- 现有研究提出了关于BMI,内分泌治疗疗效和患者存活率之间的关联的相互矛盾的证据.
研究的目的:
- 研究身体质量指数 (BMI) 对乳腺癌预后和内分泌治疗结果的影响.
- 使用孟德尔随机化 (MR) 和临床数据评估BMI和生存之间的因果关系.
主要方法:
- 一项对八项临床研究 (n=12,673) 的元分析评估了肥胖与内分泌疗法的有效性和安全性的关联.
- 一项两样本的门德尔随机化 (MR) 研究利用了遗传变异来确定BMI对接受内分泌治疗的乳腺癌患者存活率的因果关系.
主要成果:
- 综合分析表明,BMI通常不会影响内分泌治疗的整体结果.
- 服用阿纳斯特罗的超重患者的无病生存时间 (DFS) 减少,疲劳增加;使用CDK4/6抑制剂观察到更高的恶心风险.
- 服用他莫西芬的正常体重患者患有骨疼痛的风险增加. 核磁共振分析发现BMI与5年或15年生存率之间没有因果关系.
结论:
- 没有发现BMI与乳腺癌内分泌治疗的整体疗效之间有显著的关联.
- 由于它对DFS和不良事件的差异性影响,BMI在阿纳斯特罗治疗中值得考虑.
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