在2012年至2018年期间,60岁及以上的墨西哥人中,高影响性慢性疼痛和认知衰退在2012年至2018年期间发生
Sadaf Arefi Milani1, Sirena Gutierrez2, Brandon O'Grady3
1Department of Epidemiology, University of Texas Medical Branch, USA; Sealy Center on Aging, University of Texas Medical Branch, USA.
The journal of pain
|May 2, 2025
概括
墨西哥老年人的高影响性慢性疼痛与更差的基线认知有关,特别是记忆力. 然而,随着时间的推移,它与更快的认知衰退无关.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 慢性疼痛影响全球老年人,其影响因严重程度和社会经济因素而异.
- 之前的研究没有区分高影响和低影响的慢性疼痛,也没有在低收入和中等收入国家研究这一点.
- 墨西哥是一个中等收入国家,为研究老龄化人口的慢性疼痛和认知健康提供了一个独特的环境.
研究的目的:
- 调查墨西哥老年人高冲击性慢性疼痛与认知衰退之间的关联.
- 为了区分高影响与低影响慢性疼痛的认知影响.
- 分析随着时间的推移与慢性疼痛状态相关的认知变化.
主要方法:
- 利用了来自墨西哥健康与衰老研究 (MHAS) 的数据,这是一个全国代表性的60岁及以上的成年人队列.
- 疼痛分为高影响性慢性疼痛 (限制日常活动),低影响性慢性疼痛 (不限制活动) 和没有慢性疼痛.
- 使用线性混合模型与反向概率权重来评估疼痛类别和认知表现 (全球,记忆,非记忆) 之间的纵向关系.
主要成果:
- 在基线,高影响性慢性疼痛与较低的全球认知 (β: -0.024) 和记忆得分 (β: -0.042) 与没有慢性疼痛相比显著相关.
- 疼痛组之间没有观察到随着时间的推移认知能力下降的显著差异,除了记忆,高冲击性疼痛的下降速度较慢.
- 低影响性慢性疼痛与任何认知结果没有关联.
结论:
- 高影响性慢性疼痛与墨西哥老年人的基线认知功能较差有关,特别是在记忆领域.
- 虽然高冲击性疼痛不会加速认知衰退,但它与基线缺陷的关联表明潜在的潜在机制.
- 有效的疼痛管理和早期治疗可能为患有慢性疼痛的人提供认知效益.
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