艾滋病毒感染者的肝细胞癌
Claudia Am Fulgenzi1, Alessia Dalla Pria2, Alberto Giovanni Leone3
1Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, W120NN, London, UK.
Journal of hepatology
|May 2, 2025
概括
艾滋病毒感染者 (PLWH) 患肝癌 (肝细胞癌,HCC) 的风险增加. 尽管存在挑战,PLWH可以从HCC治疗中受益,但需要更多的研究.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 艾滋病毒感染者 (PLWH) 患慢性肝病和肝细胞癌 (HCC) 的风险更高,原因是他们有共同的传播途径和艾滋病毒的直接/间接影响.
- 患有HCC的PLWH的预后比没有艾滋病毒的人要差,尤其是在没有积极的癌症治疗的情况下.
- 艾滋病毒对瘤生物学和HCC治疗反应的影响仍然不完全理解.
研究的目的:
- 审查目前对PLWH中HCC病理生理学,查和管理的理解.
- 讨论对PLWH的HCC护理的挑战和差异.
- 突出PLWH与受良好控制的HIV治疗的潜在可比治疗益处.
主要方法:
- 对PLWH中HCC现有研究的文献综述.
- 综合有关病理生理学,诊断和治疗的证据.
- 讨论临床试验的局限性和护理差异.
主要成果:
- 从治愈性HCC疗法 (移植,局部区域,全身疗法) 中,PLWH可以获得与没有艾滋病毒的人相似的好处.
- 从历史上看,PLWH一直被排除在临床试验之外,导致回顾性研究的证据有限.
- 由于对艾滋病毒对HCC生物学和治疗反应的影响的不完全理解,管理方面的挑战仍然存在.
结论:
- 控制良好的艾滋病毒感染不应阻止HCC获得癌症治疗.
- 解决差异和增加PLWH在HCC临床试验中的研究参与至关重要.
- 需要进一步研究HIV在HCC瘤生物学和治疗疗效中的作用.
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