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Updated: May 15, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

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Published on: February 27, 2019

改善了用甲酸盐和PEG涂层对利科脂质体的稳定性和生物相容性

Yinglan Li¹, Jianshuo Su¹, Shufan Liu¹

¹Shandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252059, People's Republic of China.

International journal of biological macromolecules

|May 2, 2025

概括

使用甲和聚乙烯糖醇 (PEG) 的新型柳科脂质体显示出增强的稳定性和抗氧化活性. 这些表面修饰脂质体 (Lips-LYC/SC) 为功能性食品提供了一个有前途的输送系统,并改善了健康结果.

科学领域:

食品科学与技术食品科学与技术
生物材料科学生物材料科学
营养保健品营养保健品

背景情况:

利科是一种强大的抗氧化剂,具有较差的水溶性和稳定性,限制了其在功能性食品中的应用.
脂质体封装是一种提高水生物活性剂 (如利科) 的生物可用性和输送的策略.
脂质体的表面修饰可以进一步增强其物理化学特性和生物疗效.

研究的目的:

准备和表征新的表面修饰的用甲酸盐和聚乙烯甘醇 (PEG) 制备和表征的烯脂质体.
将这些修饰脂质体 (Lips-LYC/SC) 的物理化学特性和生物性能与其他配方进行比较.
评估Lips-LYC/SC作为功能性食品应用和健康益处中烯的输送平台的潜力.

主要方法:

层层地将甲酸盐和PEG组装到柳科脂质体上.
物理化学表征包括颗粒大小,稳定性,封装效率和烯泄漏分析.
光谱和热分析 (FT-IR,DSC,PXRD) 来确认辅助剂相互作用和烯结晶性降低.
在体外抗氧化剂测试 (DPPH,ROS清理) 和细胞毒性测试 (LO2,Caco-2细胞).
在高脂肪饮食 (HFD) 诱导的肝损伤模型中的体内评估.

主要成果:

与乳清蛋白分离物/PEG和PEG过的烯脂质体相比,Lips-LYC/SC显示了显著减少的颗粒大小和改善的稳定性.
在Lips-LYC/SC中,由于 kazeinate的修改,观察到更高的封装效率和最小的利科泄漏.
通过DSC,PXRD,FT-IR和光分析证实了辅助剂相互作用,改善了柳科的水溶性.
封装的利科显著增强了抗氧化活性和最小的细胞毒性.
在肝损伤模型中,Lips-LYC/SC有效改善了代谢障碍,氧化应激和肝毒性.

结论:

酸和PEG共同装饰的脂质体 (Lips-LYC/SC) 代表了烯的卓越输送系统.
这种配方增强了利科的稳定性,溶解性和抗氧化功效.
Lips-LYC/SC显示了功能性食品应用和治疗干预措施的巨大潜力,特别是肝脏健康.

关键词:

生物相容性生物相容性这种药物是百合素 (Lycopene).甲酸是一种酸盐.

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