毕通可以通过通过NF-kB通路调节抑制炎症细胞粘附来改善慢性鼻炎
Yuying Ye1, Yinyin Yao2, Shanshan He2
1Department of Otorhinolaryngology, Affiliated People's Hospital (Fujian Provincial People's Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou, 350004, China.
Journal of ethnopharmacology
|May 2, 2025
概括
毕扬通脱 (BYT) 通过通过NF-κB通路减少炎症和细胞粘附,有效治疗慢性鼻炎 (CRS). 这项研究阐明了BYT.
科学领域:
- 传统中国医药 传统中国医药
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 慢性鼻炎 (CRS) 是一种普遍的炎症性疾病.
- 传统中医药中的白云 (Biyuantong decoction,BYT) 在治疗CRS时显示出临床疗效.
- 在CRS中BYT治疗效果的基础上的精确分子机制尚未完全理解.
研究的目的:
- 研究由BYT改善CRS的分子机制.
- 提供对CRS潜在治疗策略的新见解.
主要方法:
- 临床观察和病理分析 (H&E染色,鼻内镜) 的CRS患者.
- 流细胞计和ELISA用于量化炎症细胞和细胞因子.
- 在体外测试 (细胞活力,粘附,入侵) 评估BYT对内皮细胞和炎症细胞的影响.
- 西部斑点和免疫光学分析NF-κB信号通路.
- UPLC-HRMS和网络药理学用于识别BYT组件和预测目标.
主要成果:
- 通过BYT治疗减少了鼻粘膜胀和减少了手术后的CRS复发.
- BYT显著降低了外周血液中乙酸氨基和炎症性细胞因子的水平.
- 通过降低细胞粘附分子 (CAMs) 的调节,BYT抑制了炎症细胞粘附和侵入内皮细胞的过程.
- 通过减少NF-κB相关蛋白质表达和核转位,BYT抑制了NF-κB信号通路.
结论:
- 通过通过NF-κB通路调节抑制炎症细胞粘附和透,BYT提高了CRS的临床结果.
- 这些发现支持BYT对CRS的临床使用,并强调将向炎症细胞粘附作为一种新的治疗方法.
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