在生理衰老中,酸对髓质衍生抑制细胞的作用
Yuliya V Perfilyeva1, Aikyn Kali2, Diana S Aben2
1M.A. Aitkhozhin Institute of Molecular Biology and Biochemistry, 86 Dosmukhamedov St., Almaty 050012, Kazakhstan; Almaty Branch of the National Center for Biotechnology, Central Reference Laboratory, 14 Zhahanger St., Almaty 050054, Kazakhstan.
概括
卡尔西醇 (1,25(OH) 2D) 治疗促进老年小鼠的骨髓衍生抑制细胞 (MDSC) 成熟,增强T细胞反应并减少免疫抑制. 这种维生素D形式可以缓解与年龄相关的免疫功能障碍.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 衰老研究研究 衰老研究
背景情况:
- 维生素D,特别是它的活性形式1,25(OH) 2D (酸),在调节免疫系统组件方面起着至关重要的作用.
- 之前的研究表明,1,25(OH) 2D可以降低瘤内骨髓衍生抑制细胞 (MDSC) 的数量和抑制活性.
研究的目的:
- 调查卡尔西醇给药对老年小鼠中MDSC的影响.
- 在衰老的背景下,评估酸盐是否影响MDSC表型,功能和T细胞反应.
主要方法:
- 老年小鼠 (BALB/c和CD1菌株) 接受了卡尔西醇治疗 (1μg/kg,每周两次,持续4周).
- 在和骨髓中分析了MDSC群体 (CD11b+Gr1+细胞) 的表型 (F4/80表达) 和功能 (T细胞抑制试验).
- 在体外研究中检查了酸对骨髓衍生的MDSCs的直接影响.
主要成果:
- 与年轻小鼠相比,老年小鼠的MDSC水平增加,表型不成熟,T细胞抑制活性高.
- 酸治疗增加了脏MDSC种群,并促进它们分化为更成熟的表型 (升高F4/80表达).
- 接受酸盐治疗的老年小鼠表现出改善的T细胞反应 (增加IFNγ产生) 和体外,酸盐减少了MDSC中的活性氧物种.
结论:
- 在老化过程中,MDSC扩张是不同老鼠菌株的一致特征.
- 酸有效地促进MDSC的成熟和功能,减轻老年人的免疫抑制.
- 这突显了酸在打击与年龄相关的免疫衰退方面的免疫调节潜力.
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