对逻辑回归和机器学习算法的比较,用于预测噪音引起的听力损失,并调查SNP loci
Jie Lu1, Xinhao Lu2,3, Yixiao Wang4
1Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Southeast University, Nanjing, 210009, China.
Scientific reports
|May 2, 2025
概括
机器学习模型在预测噪音引起的听力损失 (NIHL) 方面显著优于逻辑回归. 由ML模型识别的特定单核酸多态 (SNP) 位点可以提高职业听力健康的预测准确性.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 遗传学 遗传学 是一个
- 生物信息学是一种生物信息学.
背景情况:
- 噪音引起的听力损失 (NIHL) 构成一个重要的职业健康风险.
- 准确预测NIHL对于有效的预防和管理至关重要.
- 识别遗传倾向,如单核酸多态 (SNP) 位点,可以增强预测模型.
研究的目的:
- 为了比较物流回归 (LR) 和NIHL的七个机器学习 (ML) 算法的预测性能.
- 确定与NIHL发生和进展有显著关联的SNP位点.
- 使用ML和遗传数据开发一个优化的NIHL预测模型.
主要方法:
- 分析了1338名暴露于噪音的工人的队列.
- 与噪音暴露和听力损失相关的88个SNP位点被基因型化.
- 应用了LR和ML算法 (包括GRNN,PNN,GA-RF) 来构建NIHL预测模型.
- 用准确性,回忆力,精度,F-score,R2和AUC来评估模型的性能.
主要成果:
- 与传统的LR相比,ML模型,特别是GRNN,PNN和GA-RF,表现出优异的性能.
- 这些最佳的ML模型有效地处理了大规模的SNP数据.
- 识别的SNP位点对于提高NIHL预测准确度至关重要.
结论:
- 先进的ML算法为NIHL预测提供了比传统LR更有效的方法.
- 以ML为指导的SNP位点查是准确NIHL风险评估的有希望的策略.
- 这些发现为加强职业听力健康管理提供了科学基础.
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