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响应反的细胞工厂用于动态调节未折叠的蛋白质响应

Daniela Barrios1, Bhagyashree Bachhav2, Wendolyn Carlos-Alcalde3

  • 1Department of Bioengineering, Rice University, Houston, TX, USA.

Nature communications
|May 2, 2025
PubMed
概括

工程细胞工厂可以动态调整未折叠的蛋白质反应 (UPR),以减少蛋白质毒性压力,改善治疗性蛋白质的生产. 这种反响应系统提高了细胞活力和生物制剂的制造产量.

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