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增强的纳米粒子传递通过瘤的血管底层膜使用氧化

Wei Jiang1,2, Zixuan Guo1, Qin Wang3,4

  • 1National Key Laboratory of Immune Response and Immunotherapy, Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Nature biomedical engineering
|May 2, 2025
PubMed
概括

氧化 (NO) 纳米发电机突破了瘤血管底膜 (BM) 屏障,增强了纳米粒子的传递. 这种有针对性的方法可以提高瘤抑制的有效性,而不会促进转移.

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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...