在PFAPA中治疗科尔奇辛:我们应该等待多长时间才能获得临床反应?
Lutfiye Koru1, Elif Selcen Yabanci Erten2, Hatice Kubra Dursun1
1Department of Pediatric Rheumatology, Istanbul Medeniyet University Istanbul, Istanbul, Turkey.
European journal of pediatrics
|May 2, 2025
概括
科尔奇辛预防有效地减少了周期性发烧,口腔炎,喉炎和宫腺炎 (PFAPA) 的症状. 临床反应通常在治疗的第一个月内观察到.
科学领域:
- 儿科 儿科 儿科
- 类风湿病学 类风湿病学
- 遗传学 遗传学 是一个
背景情况:
- 建议对周期性发烧,口腔口炎,耳炎和宫腺炎 (PFAPA) 进行素预防.
- 在PFAPA中评估治疗反应的最佳时间尚不清楚.
- 自炎性疾病活动指数 (AIDAI) 是测量自炎性疾病中的疾病活动的验证工具.
研究的目的:
- 在PFAPA中使用AIDAI评分来评估预防性胆固醇素的疗效.
- 为了确定PFAPA患者接受菌素治疗的最佳持续时间,以评估PFAPA患者的反应.
- 在PFAPA中确定治疗反应的预测因素.
主要方法:
- 对接受素的PFAPA儿童进行了回顾性研究.
- 利用AIDAI评分系统评估喉疼痛,桃体炎和口腔口腔炎的症状.
- 收集了治疗前一个月的AIDAI分数,以及治疗开始后的1个月和3个月.
主要成果:
- 在治疗前的月份和科尔奇辛治疗的第一个月之间观察到AIDAI得分的显著下降 (p=0.002).
- 在治疗的第一个和第三个月 (p=0.463) 之间没有发现AIDAI得分的显著差异.
- 在57.9%的患者中实现了完全响应,在19.7%的患者中实现了部分响应,22.4%的患者没有反应.
结论:
- 在PFAPA中对菌素的临床反应主要发生在治疗的第一个月内.
- 对于一个月后出现部分反应的患者,建议重新评估胆固醇剂量,遵从性以及预防的必要性.
- 艾达伊评分是监测PFAPA中菌素有效性的有用工具.
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