巨对于舌头发育至关重要,因为它通过调节肌形成和血管化来调节舌头发育
Ziyao Wang1, Mengqiao Wang1, Jiani Liu1
1Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, No.44-1 Wenhua Road West, Jinan, Shandong, 250012, China.
BMC oral health
|May 2, 2025
概括
巨细胞对于正常的胎儿舌头发育至关重要. 它们的枯竭导致异常形态,肌肉形成受损,细胞死亡增加和血管生长受损.
科学领域:
- 头骨面部的发展
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
背景情况:
- 异常的舌头发育是一种面形,影响美学和功能.
- 巨细胞对心脏和大脑发育至关重要,但它们在舌头发育中的作用尚不清楚.
研究的目的:
- 为了研究巨细胞在发育中的小鼠舌头中的分布,表型和功能.
- 为了确定巨细胞枯竭对胎儿舌头发育的影响.
主要方法:
- 在小鼠胚胎上的免疫组织化学和多重免疫光学 (E13.5-E18.5).
- 使用条件淘汰赛小鼠 (CX3CR1-CreERT2; Rosa-DTA) 进行巨细胞枯竭.
- 在枯竭与对照组中分析肌形成,血管化和亡.
主要成果:
- 大细胞,主要是M2表型,在整个舌头发育过程中都存在.
- 巨细胞枯竭导致异常的舌头形态,肌肉纤维减少,亡增加,血管生长受损.
- 在血管内皮细胞中观察到VEGFA和TGF-β1的表达减少.
结论:
- 巨细胞对于胎儿的舌头发育至关重要.
- 它们会影响发育中的舌头的肌体发生,细胞亡和血管生长.
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