针对ESKAPE病原体的结合疗法:一个专利审查
Mariana Carvalho Sturaro1, Rafael Araújo1, Larissa Sobrinho Aniceto1
1Health Sciences Research Laboratory, Federal University of Grande Dourados, Mato Grosso do Sul, 79.804-970, Brazil.
Journal of applied microbiology
|May 2, 2025
概括
专利分析显示,人们对针对ESKAPE病原体的头类合疗法越来越感兴趣. 尽管临床数据有限,但专利领域突出显示了针对这些关键抗微生物耐药细菌的新兴策略.
科学领域:
- 制药科学 制药科学
- 传染性疾病 传染性疾病
- 知识产权法 知识产权法 知识产权法
背景情况:
- 逃生病原体 (Enterococcus faecium,Staphylococcus aureus,Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,Enterobacter) 是由于抗菌素耐药性而造成的全球主要健康威胁.
- 世界卫生组织强调迫切需要新的抗微生物策略,包括组合疗法.
- 类抗生素是经常在医院使用的广谱抗生素,因此它们是组合疗法的有希望的候选者.
研究的目的:
- 系统地审查针对ESKAPE病原体的基于黄素的组合疗法的专利申请.
- 分析专利申请的趋势,包括地理分布,提交实体和时间模式.
- 确定这些组合疗法的发展中的挑战和机遇.
主要方法:
- 在Espacenet数据库中使用关键词进行了全面的搜索:"组合"",抗生素"和".
- 截至2024年6月提交的专利申请被审查.
- 应用了包含标准来选择30个相关的专利申请进行分析.
主要成果:
- 总共有666个专利申请最初被确定,其中30个被选择进行分析.
- 大多数专利来自中国 (30%) 和美国 (17%),主要由私人公司申请.
- 最多的专利申请活动发生在2022年,大多数专利被归类为IPC代码A61K (制药制剂).
- 在分析的专利中,只有两项存在临床数据.
结论:
- 专利格局表明,针对ESKAPE病原体的基于黄素的组合疗法的重大创新.
- 地理和时间趋势表明越来越多的研发重点,特别是来自私营实体.
- 专利中临床数据的稀缺性凸显了验证这些新型抗菌战略的大量开发成本和挑战.
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