相关实验视频

Updated: May 9, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

针对肝细胞癌治疗中的免疫检查点:朝着具有治愈潜力的组合策略

Jing Tong^1,2, Yongci Tan^1,2, Wenwen Ouyang^1,2

¹MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510631, China.

Experimental hematology & oncology

|May 2, 2025

概括

肝细胞癌 (HCC) 治疗显示出免疫检查点抑制剂 (ICI) 的承诺,但挑战仍然存在. 本综述探讨了HCC中的ICI,旨在寻找更安全,更有效的策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

肝细胞癌 (HCC) 由于其免疫抑制的微环境和治疗结果不佳而构成重大挑战.
对HCC的传统疗法有效性有限,需要新的治疗方法.

研究的目的:

审查免疫检查点在癌症治疗中的作用.
检查免疫检查点抑制剂 (ICI) 在HCC治疗中的进展情况.
探索涉及ICI的组合策略,以改善HCC管理.

主要方法:

关于癌症治疗中的免疫检查点和ICI的文献综述.
对HCC中ICI的当前研究和临床试验数据的分析.
与ICI结合的组合疗法和新材料的评估.

主要成果:

ICI已经改变了HCC的治疗方法,但临床试验的成功率是有限的.
与ICI结合疗法显示出潜力,但面临挑战.
在HCC中ICI潜力的不足利用需要进一步调查.

结论:

在HCC中重新评估ICI对于优化其应用至关重要.
开发更安全,更有效的免疫检查点相关策略至关重要.
对ICI组合和新材料的进一步研究可以提高HCC治疗效率.

关键词:

双重ICI治疗的治疗方法肝细胞癌是肝细胞癌.这是一种ICI单疗法.基于ICI的组合疗法.免疫检查点抑制剂免疫检查点抑制剂

更多相关视频

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...