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Updated: May 9, 2025

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
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Published on: June 24, 2019

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双质性使得Schizosaccharomyces pombe中的基因组不稳定

Joshua M Park1, Daniel F Pinski1, Susan L Forsburg1

  • 1Section of Molecular & Computational Biology, University of Southern California, Los Angeles CA, 90089.

Genetics
|May 3, 2025
PubMed
概括

整个基因组重复 (多重性) 会增加癌症基因组的不稳定性和化学抵抗性. 裂变酵母研究显示,多重积分会导致DNA损伤敏感性和对特定基因的生存依赖性,为癌症进展提供了洞察力.

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During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
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