社会孤立,孤独以及与血清生物标志物,功能参数和老年人死亡率的关系
Stefanie Braig1, Michael D Denkinger2,3, Dhayana Dallmeier2,4
1Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstraße 22, 89081, Ulm, Germany. stefanie.braig@uni-ulm.de.
Aging clinical and experimental research
|May 3, 2025
概括
社会隔离 (SI) 和孤独影响健康. 总体SI高与功能参数较差以及老年人10年死亡风险增加有关.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 生物医学科学 生物医学科学
背景情况:
- 连接社会隔离 (SI) 和孤独与健康结果的确切途径仍然不完全理解.
- 研究这些联系对于理解衰老和疾病预防至关重要.
研究的目的:
- 调查社会隔离和孤独与炎症生物标志物,心脏功能,免疫功能和功能参数之间的联系.
- 分析社会隔离和孤独与老年人长期死亡率之间的关系.
主要方法:
- 德国的一项基于人口的队列研究,涉及1459名65岁及以上的社区成年人.
- 社会孤立 (使用卢本社会网络尺度) 和孤独在基线时被评估.
- 生物标志物 (hs-CRP,GDF-15,NT-proBNP,hs-cTnI,hs-cTnT) 和功能参数 (步行速度,手握强度) 在基线和三年随访时被测量.
主要成果:
- 在随访时,与朋友的高度社会隔离显示出与某些生物标志物 (hs-CRP,GDF-15,hs-cTnT) 的小但显著的不良关联.
- 对家庭的高度社会隔离与NT-proBNP有关,高SI和中度至重度的孤独与较低的步行速度有关.
- 总体而言,高度的社会隔离比孤独更强烈地预测生物标志物水平,并且与10年死亡率的增加有关 (HR 1.39).
结论:
- 社会隔离,特别是与朋友的隔离,与不利的生物标志物概况有关,尽管关联通常很小.
- 总体而言,社会孤立对功能参数产生负面影响,并且与老年人长期死亡率有积极的关联.
- 建议采用多维孤独评估的进一步研究来验证这些发现.
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