与代谢功能障碍相关的脂肪性肝病是胆结石的危险因素:一个多中心队列研究
Tomonori Cho1, Shuhei Fukunaga1, Daiki Ohzono1
1Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 显著增加了胆结石风险. 适度饮酒 (MetALD) 不会增加风险,甚至可能减少MASLD患者的风险. 高血压是MASLD相关胆结石发展的关键因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 代谢疾病 代谢疾病
背景情况:
- 胆结石的形成与代谢功能障碍有关.
- 脂肪性肝病 (SLD) 的新定义包括代谢功能障碍相关的SLD (MASLD) 和中度酒精摄入量 (MetALD).
研究的目的:
- 调查MASLD和MetALD对胆结石发展的影响.
- 为了确定患有MASLD的患者胆结石形成的危险因素.
主要方法:
- 一项8766名健康检查受试者的多中心观察队列研究.
- 患者被分为非SLD,MASLD或MetALD组.
- 使用多变量考克斯回归和随机森林分析.
主要成果:
- 与非SLD相比,MASLD独立增加了胆结石风险 (HR 1.7112).
- 此外,MASLD的风险也高于MetALD (HR 1.3516).
- 高血压被确定为MASLD患者胆结石的主要心脏代谢风险因素.
结论:
- MASLD是胆结石发展的独立风险因素.
- 甲甲D具有与非SLD相似的风险,并且可能降低MASLD患者的胆结石风险.
- 高血压是MASLD相关的胆结石形成的一个重要因素.
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