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Updated: May 9, 2025

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针对ICOS/ICOS-L蛋白与蛋白相互作用的单环抑制剂的计算设计

Laura Calvo-Barreiro1, Maxim Secor2, Jovan Damjanovic2

  • 1Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, New York, USA.

Chemical biology & drug design
|May 3, 2025
PubMed
概括

研究人员通过计算设计了CP5,这是一种针对可诱导T细胞共刺激分子 (ICOS) 和其连接体 (ICOS-L) 相互作用的双循环抑制剂. 这种对进一步的免疫调节药物开发充满希望.

关键词:
这就是ICOS ICOS.循环酸是循环酸的一种.免疫检查点的检查点.在形设计中.蛋白质蛋白质相互作用

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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