在结直肠癌中Polo-Like激酶1的表达:与RAS突变的关联
Yasushi Tanaka1,2, Eiji Oki1, Ryota Nakanishi1
1Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Cancer science
|May 3, 2025
概括
高波罗样激酶1 (PLK1) 表达预测结直肠癌 (CRC) 患者的不良结果,特别是那些接受辅助化疗和RAS突变的患者. 需要进一步的研究来探索PLK1作为预后生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症生物标志物 癌症生物标志物
背景情况:
- 波罗样酶1 (PLK1) 对于细胞分裂至关重要.
- 它在结直肠癌 (CRC) 的预后价值,特别是RAS突变的预后价值,尚不清楚.
- 了解PLK1的作用可以改善CRC治疗策略.
研究的目的:
- 研究PLK1表达作为结直肠癌 (CRC) 治疗结果的预测生物标志物.
- 分析PLK1表达,临床病理因素和CRC患者的存活率之间的相关性.
- 评估RAS突变对CRC预后的影响.
主要方法:
- 对225名结直肠癌 (CRC) 患者的回顾性分析.
- 评估的PLK1表达水平.
- 与临床病理因素,生存率和RAS突变状态相关联的PLK1表达.
主要成果:
- PLK1的表达显著与组织病理学和围神经侵袭相关.
- 高PLK1表达与所有CRC患者和III期患者的无复发生存率下降的趋势有关.
- 在接受辅助化疗的III期CRC患者中,高PLK1表达是无复发生存的独立不良预后因素.
- 与野生型RAS相比,突变的RAS状态显著预测了较差的预后.
结论:
- 高PLK1表达与接受辅助化疗的结直肠癌 (CRC) 患者的生存率低下有关.
- PLK1可以作为预测CRC治疗结果的生物标志物.
- RAS突变状态是CRC的显著预后因素,可能与PLK1表达相互作用.
更多相关视频
10:13A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
Published on: July 3, 2013
11.0K
09:29Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
13.6K
相关概念视频
The Ras Gene
6.1K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
Ras is a...
6.1K
Small GTPases - Ras and Rho
3.8K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
3.8K
mTOR Signaling and Cancer Progression
3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.6K
PI3K/mTOR/AKT Signaling Pathway
3.3K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.3K
Abnormal Proliferation
4.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.3K
MAPK Signaling Cascades
4.9K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
4.9K
